BNT162b2 Vaccine Proteomic Changes: Longitudinal Plasma Protein Levels in Qatar

354 plasma proteins were quantified in 70 individuals before and after a COVID-19 booster dose. The longitudinal study, conducted by Sana Bentebbal, tracked protein levels at 3- and 6-months post-booster in both infection-naïve and previously infected participants. Results highlight sustained changes in proteins like PARP-1 and MMP-7, offering insights into post-vaccination inflammatory processes.

Use Cases

• Identify sustained protein biomarkers of vaccine response based on longitudinal proteomic profiling.
• Compare immune proteome dynamics between infection-naïve and previously infected individuals based on cohort stratification.
• Analyze fold-change and statistical significance of specific proteins like PARP-1 and MMP-7 based on reported results.

Strengths

• Quantifies 354 unique plasma proteins using Olink technology.
• Includes longitudinal data from 70 individuals across three time points.
• Stratifies cohort into 35 infection-naïve and 35 previously infected participants.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the Qatar-based cohort.

Provenance

Source

figshare

Collection Method

Plasma protein quantification via Olink technology in a longitudinal cohort study.

Time Range

Data collection likely spans a 6-month period post-booster vaccination.

Freshness

Last updated 2026-04-24 05:37:10; freshness should be verified.

Geography

Qatar