Case Report of Probable Metformin-Associated Erythema Multiforme

A single case report describes a 51-year-old man developing erythema multiforme ten days after starting metformin therapy. Authored by Long Luo and published under CC-BY-4.0 on figshare in May 2026, the document provides a practical reference for causality assessment in polypharmacy settings. This is reportedly only the second English-language case of this specific phenotype since 2004.

Use Cases

• Training causality assessment algorithms based on the structured narrative of drug discontinuation and reintroduction.
• Studying rare adverse event phenotypes based on the detailed clinical description of targetoid skin lesions.
• Benchmarking pharmacovigilance case reports based on the documented timeline and differential diagnosis process.
• Informing clinical guidelines for managing suspected drug reactions in patients on multiple medications.

Strengths

• Provides a detailed, peer-reviewed clinical narrative of a very rare adverse event.
• Includes a specific causality assessment ('probable') and a clear timeline of symptom onset and resolution.
• Offers a practical methodological reference for identifying culprit agents in polypharmacy.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Represents a single case report (n=1), limiting statistical generalizability.

Provenance

Source

Long Luo

Collection Method

Clinical case report and literature review.

Time Range

Case occurred at an unspecified date; report published in 2026.

Freshness

Last updated 2026-05-14 14:22:02; freshness should be verified.