Proenkephalin A 119–159 Levels in 100 End-Stage Kidney Disease Patients

A prospective cohort study of 100 adult patients with end-stage kidney disease undergoing maintenance hemodialysis, conducted by Luobei Zhang. Plasma Proenkephalin A 119–159 levels were measured before and after a dialysis session and analyzed for correlation with estimated glomerular filtration rate and other markers. The dataset was last updated on April 14, 2026.

Use Cases

• Analyze the correlation between Proenkephalin A 119–159 and estimated glomerular filtration rate based on baseline measurements.
• Evaluate the clearance of Proenkephalin A 119–159 during hemodialysis compared to markers like BUN and SCr.
• Investigate associations between Proenkephalin A 119–159 and other clinical markers such as NT-proBNP and LVEF.
• Assess the stability of Proenkephalin A 119–159 levels across patient subgroups based on residual urine output or dialysis vintage.

Strengths

• Includes data from 100 patients, providing a specific cohort size.
• Contains paired measurements (pre- and post-dialysis) for Proenkephalin A 119–159 and other markers.
• Reports specific median values for eGFR (6.30 mL/min/1.73 m²) and PENK (4.88 ng/mL).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is from a single-center study, which may limit generalizability.

Provenance

Source

Luobei Zhang via figshare.

Collection Method

Single-center prospective cohort study; plasma levels determined via double-antibody sandwich enzyme-linked immunosorbent assay.

Freshness

Last updated 2026-04-14 04:14:28; freshness should be verified.