Meta-Analysis of SPECT/CT Prognostic Value in Prostate Cancer Therapy

Seven studies comprising 648 patients were analyzed in this systematic review and meta-analysis. Amirreza Shamshirgaran authored the work, which was uploaded to figshare on April 24, 2026. It evaluates the prognostic value of interim post-treatment SPECT/CT imaging parameters for survival outcomes in metastatic castration-resistant prostate cancer patients.

Use Cases

• Evaluating the prognostic significance of new lesions on SPECT/CT scans for overall survival.
• Assessing the predictive value of total tumor volume (TTV) increases for PSA-progression-free survival.
• Investigating the relationship between SUVmean and SUVmax reductions and patient outcomes.
• Supporting the standardization of radiologic monitoring protocols for lutetium-177-PSMA therapy.

Strengths

• Analysis is based on 648 patient records aggregated from seven studies.
• Follows PRISMA guidelines and PICO framework for systematic review methodology.
• Results include pooled hazard ratios with confidence intervals and p-values for key parameters.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a single 11.8 KB document, indicating a limited scope of raw data.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed/MEDLINE, Scopus, and Google Scholar.

Time Range

Studies searched up to December 2025.

Freshness

Last updated 2026-04-24 04:21:33; freshness should be verified.