MAIT Cell Phenotype and Function in Sepsis-Related Liver Injury

47 sepsis-related liver injury patients, 37 non-septic liver injury patients, 34 sepsis patients without liver injury, and 115 healthy controls were analyzed for mucosal-associated invariant T cell frequency, phenotype, and cytokine production. The dataset likely contains flow cytometry measurements from a clinical cohort and murine model experiments. It was authored by Wei Bu and last updated on April 15, 2026.

Use Cases

• Analyze MAIT cell frequency and phenotype changes based on patient group classifications mentioned in the description
• Model the relationship between bilirubin levels and MAIT cell activation/exhaustion based on in vitro assay results
• Compare liver injury severity and inflammatory cytokine levels based on murine model outcomes between wild-type and MAIT-deficient mice
• Investigate Th17-like differentiation bias in MAIT cells based on cytokine production profiles (IL-17A, TNF-α, granzyme B)

Strengths

• Includes data from 233 human subjects across four distinct clinical groups
• Integrates findings from both a clinical cohort and a murine model
• License is CC-BY-4.0, permitting open reuse

Limitations

• Row count and column-level documentation are unknown
• The dataset is very small (13.7 KB), indicating limited scope
• The file format is DOCX, which may require conversion for analysis

Provenance

Source

figshare

Collection Method

Clinical cohort analysis and murine model experiments

Freshness

Last updated 2026-04-15 05:44:20