Proteome-Wide Mendelian Randomization Results for Schizophrenia Biomarker Discovery

Jingyu Lin's 2026 study presents results from proteome-wide Mendelian randomization and colocalization analyses to identify causal plasma proteins for schizophrenia. The primary analysis used genetic instruments for 4,907 plasma proteins from 35,559 Icelanders and summary statistics for schizophrenia from 35,476 cases and 46,839 controls. Findings were validated using external datasets including the Fenland study and UK Biobank Pharma Proteomics Project.

Use Cases

• Prioritizing candidate plasma protein biomarkers for schizophrenia based on reported odds ratios and p-values.
• Conducting colocalization analyses to assess shared causal variants between protein levels and schizophrenia risk.
• Exploring protein-protein interaction networks with known antipsychotic drug targets.
• Validating genetic associations using external pQTL and eQTL data sources mentioned in the description.

Strengths

• Primary analysis includes genetic data for 4,907 plasma proteins from a cohort of 35,559 individuals.
• Schizophrenia outcome data is based on a large sample of 35,476 cases and 46,839 controls from the Psychiatric Genomics Consortium.
• Results were externally validated using multiple independent datasets (Fenland, UKB-PPP, GTEx).
• Specific statistical results are provided, including odds ratios and p-values for seven identified proteins.

Limitations

• The dataset is a 26.1 KB DOCX file containing summary results, not the underlying raw genetic or proteomic data.
• Column-level documentation is absent; field semantics must be inferred from the manuscript text.
• Row count is unknown, which may limit suitability assessment for direct computational analysis.

Provenance

Source

figshare, author Jingyu Lin.

Collection Method

Proteome-wide Mendelian randomization and colocalization analyses using genetic association data.

Time Range

The study was posted in 2026; specific temporal coverage of the underlying genetic data is not detailed.

Freshness

Last updated 2026-03-18 07:41:54.

Geography

Primary genetic instrument data is from 35,559 Icelanders; validation uses UK-based cohorts (Fenland, UK Biobank).