Quercetin Effects on Skin Inflammation and Fibrosis in Systemic Sclerosis

A 22.7 KB document by Xiangzhen Kong, last updated June 3, 2026, details a study on the flavonoid quercetin. The research utilized primary CD4+ T cells from systemic sclerosis patients and a bleomycin-induced mouse model. Findings suggest quercetin binds transcription factors RELA and c-Jun to suppress Th17 cell responses and skin fibrosis.

Use Cases

• Identify potential drug targets for autoimmune fibrosis based on the described RELA/c-Jun axis.
• Model immunomodulatory effects of flavonoids based on cytokine suppression data mentioned in the description.
• Validate in vitro to in vivo translation of drug effects based on the described patient-derived cell and mouse model workflow.

Strengths

• 22.7 KB document provides a detailed methodological description of the study.
• Research includes validation using both patient-derived cells and an in vivo mouse model.

Limitations

• The dataset is a single 22.7 KB document; no structured data tables are confirmed.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Xiangzhen Kong

Collection Method

Laboratory study utilizing primary CD4+ T cells from patients and a bleomycin-induced mouse model.

Freshness

Last updated 2026-06-03 05:16:39; freshness should be verified.