Table 2_Radiotherapy plus immune checkpoint inhibitors versus immune checkpoint inhibitors

A systematic review and meta-analysis of six comparative cohort studies, comprising 1,631 patients, investigating the combination of radiotherapy and immune checkpoint inhibitors versus immunotherapy alone for non-small cell lung cancer with bone metastases. The analysis was conducted by Yingding Ruan and published on figshare in March 2026. It pools hazard ratios for survival outcomes and odds ratios for binary outcomes from studies published between January 2010 and October 2025.

Use Cases

• Compare overall survival and progression-free survival outcomes between treatment regimens based on pooled hazard ratios.
• Assess the impact of combined therapy on skeletal-related events based on reported odds ratios.
• Evaluate the safety profile of combined therapy by analyzing reported rates of grade ≥3 adverse events.
• Inform the design of prospective clinical trials based on the synthesized evidence from observational studies.

Strengths

• Includes data from 1,631 patients across six studies, providing a quantitative synthesis.
• Reports specific pooled effect sizes with confidence intervals (e.g., OS HR 0.58, 95% CI 0.44–0.76).
• Assesses multiple clinical outcomes: overall survival, progression-free survival, objective response rate, adverse events, and skeletal-related events.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The authors note the evidence is of low to moderate quality and based on observational studies, limiting causal inference.
• The estimate for skeletal-related events is based on sparse event data, as noted in the conclusions.

Provenance

Source

figshare, author Yingding Ruan.

Collection Method

Systematic review and meta-analysis pooling data from PubMed, Cochrane Library, Web of Science, Scopus, and Embase.

Time Range

Studies published from January 2010 to October 2025.

Freshness

Last updated 2026-03 -17 13:09:24; freshness should be verified.

Geography

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