Breg-Related Gene Signature for Head and Neck Cancer Prognosis and Immune Analysis
by Junyan He·Updated 2mo ago
12.3 KB1files
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Description
An eight-gene prognostic signature derived from TCGA and GEO cohorts predicts survival and immune landscape in head and neck squamous cell carcinoma. The signature, created by Junyan He and last updated in April 2026, is linked to tumor mutation burden, immune checkpoint expression, and drug sensitivity. Functional analyses identified OLR1 as a key oncogenic gene associated with immune evasion in this cancer type.
Use Cases
Building prognostic models for HNSCC patient survival based on the eight-gene Breg-related signature.
Analyzing associations between gene signature risk scores and tumor mutation burden (TMB) or immune checkpoint expression.
Investigating potential biomarkers for immunotherapy response prediction as suggested by the study's conclusions.
Studying immune cell infiltration patterns in HNSCC tumors using techniques like ESTIMATE referenced in the methods.
Strengths
Signature validated across multiple cohorts from TCGA and GEO databases.
The model integrates risk scores with clinicopathological features and TMB for improved prognostic accuracy.
File size is 12.3 KB, indicating a compact and focused dataset.
Limitations
Row count and column-level documentation are unknown, which may limit suitability assessment.
Description metadata is limited; actual data quality requires manual inspection after download.
Provenance
Source
The Cancer Genome Atlas (TCGA)-HNSCC and Gene Expression Omnibus (GEO) databases.
Collection Method
Analysis involved consensus clustering, Cox regression (univariate, LASSO, multivariate), WGCNA, GSEA, and ESTIMATE for immune infiltration assessment.
Time Range
null
Freshness
Last updated 2026-04-10 05:58:07; freshness should be verified.