Ceftriaxone Tolerance and Reinfection in Recurrent Gonorrhoea: A Case Report with Lab Data

Four clinical isolates of Neisseria gonorrhoeae from a patient series between 2022 and 2025. Data includes results from tolerance disc testing, growth curves, MDK99 assays, and a Galleria mellonella infection model, integrated with whole-genome sequencing. The dataset was authored by Izumo Kanesaka and published on figshare in April 2026.

Use Cases

• Analyzing bacterial killing kinetics based on MDK99 values across ceftriaxone concentrations.
• Comparing growth trajectories between tolerant and non-tolerant bacterial variants.
• Correlating genomic sequence types with clinical reinfection events.
• Evaluating the Galleria mellonella model for assessing antibiotic efficacy in vivo.

Strengths

• Data integrates multiple complementary laboratory assays (tolerance disc testing, MDK99, growth curves, in vivo model).
• Includes whole-genome sequencing results for genomic typing.
• Focuses on a specific, clinically relevant case of recurrent infection with four isolates.

Limitations

• Row count and specific column-level documentation are unknown.
• The dataset is very small at 17.7 KB, indicating limited scope.
• Data may reflect bias inherent to a single clinical case series.

Provenance

Source

figshare, authored by Izumo Kanesaka.

Collection Method

Clinical isolates underwent laboratory assays including tolerance disc testing, growth curves, MDK99 measurement, and a Galleria mellonella infection model, supplemented by whole-genome sequencing.

Time Range

Clinical isolates were obtained between 2022 and 2025.

Freshness

Last updated 2026-04-23 05:35:00.