Immune Cell and Metabolite Associations with Intrahepatic Cholangiocarcinoma

A dataset presenting results from a two-sample Mendelian randomization study investigating causal links between immune cell phenotypes, blood metabolites, and intrahepatic cholangiocarcinoma (ICC). The study identified three specific immune traits as risk factors and two potential metabolite mediators, with findings validated through in vitro experiments on HuCC-T1 and RBE cells. The dataset was authored by Zhipeng Ye and last updated on May 22, 2026.

Use Cases

• Validate causal relationships between immune cell profiles and cancer risk based on Mendelian randomization results.
• Investigate the role of specific metabolites like N-acetylleucine and fructosyllysine as molecular mediators in cancer pathways.
• Design follow-up experiments targeting the DLAT-leucine metabolic axis based on the in vitro validation results.
• Perform sensitivity analyses for genetic association studies using the described inverse variance weighted method and pleiotropy tests.

Strengths

• Includes specific odds ratios and confidence intervals for three identified immune trait risk factors (e.g., OR = 1.0005 for activated CD4 regulatory T cells).
• Results are supported by sensitivity analyses that reportedly found no horizontal pleiotropy or heterogeneity.
• Genetic findings are experimentally validated through in vitro cell line experiments (HuCC-T1 and RBE cells).
• Dataset is openly licensed under CC-BY-4.0.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• The dataset is small (694.9 KB), indicating a limited scope focused on summary-level results rather than raw genetic data.

Provenance

Source

figshare, authored by Zhipeng Ye.

Collection Method

Two-sample Mendelian randomization analysis with mediation analysis and in vitro experimental validation.

Freshness

Last updated 2026-05-22 06:10:28; freshness should be verified.