Table 2_Remodeling the gut-heart axis: Danggui Sini granule mitigates vasospastic coronary

A 2026 study by Haipeng Tang investigates the cardioprotective mechanisms of Danggui Sini Granule in a rat model of vasospastic coronary heart disease. The dataset includes pharmacodynamic evaluations, 16S rRNA gut microbial profiles, and untargeted serum metabolomics data, integrated with network pharmacology and molecular docking analyses. It is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Analyzing gut microbiota shifts (e.g., Lactobacillus, Escherichia) in response to herbal treatment based on 16S rRNA sequencing data.
• Investigating lipid metabolic reprogramming (e.g., linoleic acid pathways) based on untargeted serum metabolomics results.
• Validating predicted multi-omics pathway links (e.g., PPAR, PI3K-Akt) using the provided joint enrichment and molecular docking data.
• Studying correlations between systemic inflammatory markers (TNF-α, IL-6) and myocardial injury metrics in a disease model.

Strengths

• Integrates multi-omics data including 16S rRNA sequencing and untargeted metabolomics from a controlled rat model.
• Includes molecular docking results suggesting binding affinities for key components like Quercetin to targets such as PIK3CA and NOS3.
• Shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is very small (15.7 KB), suggesting it is likely a summary document rather than raw experimental data.
• Column-level documentation and sample data are unavailable, requiring manual inspection after download.
• Data is from an animal model; direct applicability to human biology may be limited.

Provenance

Source

figshare, author Haipeng Tang.

Collection Method

Data generated from a rat model of vasospastic CHD, with treatment using Danggui Sini Granule and subsequent multi-omics analysis.

Freshness

Last updated 2026-05-22.