RZV Vaccine: Repeated Dose Toxicity and Immunogenicity in SD Rats

17.8 KB of tabular data from a non-clinical safety assessment of a recombinant zoster vaccine (CHO cell) formulated with adjuvant BC02. The study, conducted by Qian Yang, involved administering four doses to adult Sprague-Dawley rats and assessed safety via health observations, immunotoxicity assays, hematology, biochemistry, and histopathology. The no-observed-adverse-effect level (NOAEL) was determined to be 1.0 mL per rat, equivalent to two human doses.

Use Cases

• Benchmarking vaccine safety endpoints based on general health observations and histopathological evaluations mentioned in the description
• Analyzing immunogenicity profiles based on cellular and humoral response data described
• Modeling dose-response relationships based on the NOAEL and dosing schedule described
• Comparing adjuvant effects based on data from the adjuvant control group mentioned

Strengths

• Data is from a systematic toxicology program supporting clinical trial progression, as stated in the description
• Includes multiple assessment modalities: immunotoxicity, hematology, biochemistry, and histopathology
• Specific NOAEL value (1.0 mL per rat) is reported

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data scale is limited (17.8 KB), indicating a small dataset

Provenance

Source

figshare

Collection Method

Experimental study data from a non-clinical safety assessment program.

Freshness

Last updated 2026-05-22 05:35:49; freshness should be verified