Retinoic Acid Antiviral Effects on PRRSV Infection Transcriptomics

Transcriptomic data from a study investigating the antiviral effects of all-trans retinoic acid (ATRA) against Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The dataset contains results from experiments on MARC-145 cells and primary porcine alveolar macrophages (PAMs). It was authored by Jintong Guo and published under a CC BY 4.0 license in 2026.

Use Cases

• Analyze transcriptomic profiling data to identify genes and pathways upregulated by ATRA treatment in uninfected PAMs.
• Compare transcriptomic signatures between PRRSV-infected and ATRA-treated PAMs to study the reversal of hyperinflammatory responses.
• Investigate the regulatory effects of ATRA on lipid homeostasis pathways disrupted by PRRSV infection.
• Evaluate the correlation between ATRA-induced immune signaling pathway changes and the inhibition of PRRSV replication.

Strengths

• Data originates from a controlled experimental study with transcriptomic profiling, providing mechanistic insights.
• Includes results from two relevant cell models: MARC-145 cells and primary porcine alveolar macrophages (PAMs).
• Dataset is openly available under a permissive CC BY 4.0 license for reuse.

Limitations

• The dataset is very small at 69.8 KB, indicating limited scope, likely containing summary results rather than raw sequencing data.
• Sample size and specific row/column counts for the transcriptomic data are not provided, limiting assessment of statistical power.
• Findings are specific to PRRSV and porcine cell models, limiting direct applicability to other viruses or hosts.

Provenance

Source

Figshare, authored by Jintong Guo.

Collection Method

Generated from laboratory experiments evaluating ATRA efficacy and subsequent transcriptomic profiling via RNA sequencing.

Freshness

Last updated in March 2026, indicating recent data.