PTIP and EphA2 Expression in Esophageal Squamous Cell Carcinoma

Xiao Han published Table_2_RETRACTED on figshare in May 2026. The dataset likely contains experimental results analyzing the role of Pax2 transactivation domain-interacting protein (PTIP/PAXIP1) in regulating ephrin type-A receptor 2 (EphA2) expression and cell invasion in esophageal squamous cell carcinoma (ESCC). It is a 676.1 KB Excel file released under a CC-BY-4.0 license.

Use Cases

• Correlating PTIP expression levels with lymph node metastasis status based on immunohistochemistry data.
• Modeling the regulatory relationship between PTIP and EphA2 expression based on integrated RNA-seq and ChIP-seq analysis.
• Investigating the role of Fosl2 competition with PTIP in modulating ESCC cell invasion.
• Identifying potential therapeutic targets for ESCC treatment based on PTIP-EphA2 pathway modulation.

Strengths

• Dataset is focused on a specific molecular pathway (PTIP-EphA2) in a defined cancer type (ESCC).
• Data integrates multiple experimental approaches (immunohistochemistry, RNA-seq, ChIP-seq) as described.
• Published under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The file is titled 'RETRACTED', which may indicate a data integrity issue requiring verification.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from immunohistochemistry, RNA-seq, and ChIP-seq analyses of ESCC tissues and cells.

Freshness

Last updated 2026-05-28 11:53:45; freshness should be verified.