Post-hoc Analysis of nVNS Treatment Outcomes for Chronic mTBI with PTSD

Michael Ament published a retrospective post-hoc subgroup analysis on figshare in April 2026. The study analyzes symptom severity changes in adults with chronic mild traumatic brain injury and comorbid PTSD treated with adjunctive non-invasive vagus nerve stimulation. It reports Neurobehavioral Symptom Inventory scores at baseline and after 3–4 months of treatment.

Use Cases

• Analyze symptom burden reduction based on reported changes in total Neurobehavioral Symptom Inventory scores
• Identify high-symptom-burden phenotypes based on multivariate analyses described in the study
• Evaluate treatment responsiveness based on the percentage of patients achieving ≥30% symptom reduction
• Compare improvements across affective, cognitive, somatic, and vestibular symptom domains

Strengths

• Includes specific quantitative results, such as mean total NSI scores decreasing from 2.50 ± 0.60 to 2.03 ± 0.46
• Reports domain-specific improvements with statistical significance (FDR-corrected q-values)
• Identifies patient subgroups achieving clinically meaningful improvement (40% with ≥30% reduction)

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data may reflect temporal/source bias inherent to a single retrospective observational cohort

Provenance

Source

Michael Ament

Collection Method

Post-hoc subgroup analysis of a previously published retrospective observational cohort

Freshness

Last updated 2026-04-13 05:44:22