Key Biomarkers and Molecular Mechanisms of DEHP in Skin Cancer

11 key targets for DEHP-induced skin cancer were identified through network toxicology and molecular docking. The study validated target dysregulation using TCGA/GTEx transcriptomic data, HPA proteomic data, and RT-qPCR experiments. Haidong Zhou authored this research, last updated on 2026-05-21.

Use Cases

• Identifying potential therapeutic targets based on the 11 key biomarkers like CTNNB1 and AKT1.
• Analyzing pathway disruption in skin cancer based on associations with Jak-STAT and PI3K-Akt/mTOR pathways.
• Validating gene expression patterns in skin cancer subtypes using the referenced transcriptomic and proteomic data.

Strengths

• Identifies 11 specific molecular targets (e.g., CTNNB1, ESR1, AKT1) linked to DEHP exposure.
• Validation employs multiple data sources: TCGA/GTEx transcriptomics, HPA proteomics, and in vitro cellular experiments.
• The study constructs a four-tier regulatory network linking 'DEHP-core targets-pathways-skin cancer'.

Limitations

• The dataset is a 321.6 KB DOCX file, indicating a limited scope primarily containing textual results rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Integrates network toxicology, molecular docking, and experimental validation using multiple databases and lab experiments.

Freshness

Last updated 2026-05-21 04:19:26; freshness should be verified.