Risk Factors for Cutaneous Immune-Related Adverse Events: A Systematic Scoping Review

50 studies encompassing 198,514 cancer patients were analyzed to identify risk factors for cutaneous immune-related adverse events (cirAEs). The review, authored by Zhenzhen Su and last updated in April 2026, found 12.5% of participants experienced at least one cirAE, with 68 distinct risk factors identified across demographic, clinical, and biomarker domains.

Use Cases

• Identify demographic risk factors for cirAEs based on reported associations with age, gender, and BMI.
• Analyze clinical risk factors based on tumor type (e.g., melanoma) and specific treatment regimens (e.g., camrelizumab).
• Investigate biomarker associations based on reported eosinophil count and cytokine levels.
• Validate reported odds ratios (OR) for specific cirAE subtypes like maculopapular rash and pruritus.

Strengths

• Systematic review methodology following PRISMA-ScR guidelines, covering studies from 10 major databases.
• Analysis of 198,514 participants provides a substantial patient cohort for risk factor identification.
• Identifies 68 distinct risk factors categorized into three primary domains.

Limitations

• Data is a 37.5 KB DOCX file summarizing a review; the underlying raw data is not provided.
• The review notes significant variability in the quality of reporting for risk factors across included studies.
• Row count and column-level documentation for any underlying data are unknown.

Provenance

Source

Author: Zhenzhen Su. Platform: figshare.

Collection Method

Systematic scoping review conducted via searches in PubMed, Embase, Cochrane, Web of Science, ProQuest, CINAHL, CNKI, Wanfang Data, VIP, and SinoMed.

Time Range

Literature review from database inception to December 31, 2023.

Freshness

Last updated 2026-04-16; review covers literature up to December 31, 2023.

Geography

Studies included were published in English and Chinese, suggesting a global scope with specific regional inclusion.