YWHAZ RNA-Seq and iRIP-Seq Data for Diabetic Foot Ulcer Research

Tianjian Zha published a dataset on figshare in May 2026 containing RNA sequencing and immunoprecipitation data related to diabetic foot ulcers. The data includes results from an analysis of the RNA-binding protein YWHAZ, its differentially expressed genes, and binding targets. The dataset is stored in an XLS file and is licensed under CC-BY-4.0.

Use Cases

• Identify differentially expressed genes based on RNA-seq results from YWHAZ knockdown experiments.
• Analyze RNA-binding motifs based on iRIP-seq results indicating YWHAZ binds to GC-rich sequences.
• Investigate pathways like insulin resistance and signaling based on KEGG analysis results mentioned for gene SREBF1.
• Study correlations between gene expression and cellular behaviors like proliferation and apoptosis described in the experimental results.

Strengths

• Dataset is derived from multiple experimental methods including RNA-seq and iRIP-seq, as described.
• Analysis identified 1,072 differentially expressed genes and 57 specific YWHAZ-bound DEGs.
• Expression validation was performed using RT-qPCR and immunohistochemistry.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 675.0 B, indicating limited raw data scope.

Provenance

Source

Tianjian Zha via figshare.

Collection Method

Generated from laboratory experiments including RNA-seq, iRIP-seq, RT-qPCR, and immunohistochemistry on DFU tissues and HaCaT cells.

Freshness

Last updated 2026-05-07 04:47:33; freshness should be verified.