Table 2_S-ketamine mitigates paclitaxel-induced pain-related anxiety-like behavior through

A preclinical research dataset from a mouse model investigating the effects of S-ketamine on paclitaxel-induced neuropathic pain and anxiety-like behavior. The data, authored by Jing Cao and last updated in April 2026, includes results from behavioral tests (electronic von Frey, elevated plus maze, open field), electrophysiological recordings, and molecular analyses (Western blot, immunofluorescence) focusing on the prelimbic cortex. The dataset is shared under a CC-BY-4.0 license.

Use Cases

• Analyzing correlations between mechanical withdrawal thresholds and molecular marker expression based on behavioral and Western blot data mentioned in the description.
• Modeling the relationship between pyramidal neuron firing rates and anxiety-like behaviors based on electrophysiological and elevated plus maze test results.
• Investigating the co-modulation of mGluR5 and BDNF/TrkB signaling pathways in a preclinical pain model based on the described molecular analyses.

Strengths

• Dataset is associated with a detailed methodological description including specific behavioral tests (electronic von Frey, EPM, OFT) and molecular techniques (Western blot, immunofluorescence).
• The research context is clearly defined, focusing on a specific chemotherapy agent (paclitaxel), a treatment (S-ketamine), and brain region (prelimbic cortex).
• Shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is very small at 79.7 KB, indicating limited scope or a summary table rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.

Provenance

Source

figshare, author Jing Cao.

Collection Method

Data likely generated from a controlled laboratory study involving intraperitoneal paclitaxel injections in mice, followed by behavioral testing, electrophysiology, and molecular biology assays.

Freshness

Last updated 2026-04-23 05:36:34; freshness should be verified.