Systematic Review of S100 Protein Roles in IgA Vasculitis

Fifty-four studies were synthesized in this systematic review investigating S100 proteins in IgA vasculitis and other systemic vasculitides. The review, authored by Zofia Podraza and updated in March 2026, evaluates S100A8/9, S100A12, S100A4, and S100A10 as potential biomarkers for disease activity and prognosis.

Use Cases

• Analyze the evidence for **S100A8/9** and **S100A12** as markers of neutrophil-driven inflammation and disease activity in systemic vasculitides.
• Compare the fragmentary findings on **S100A4** and **S100A10** to identify gaps in IgAV-specific mechanistic data.
• Synthesize conclusions on the potential of **S100 proteins** as mediators in the IgAV inflammatory cascade for biomarker research.
• Evaluate the systematic review's narrative synthesis of 54 studies to inform future standardized prospective studies on **S100A12**.

Strengths

• Synthesizes findings from **54** included human studies on a specific biological pathway.
• Focuses on four specific **S100 protein** types (S100A8/9, S100A12, S100A4, S100A10) for targeted analysis.
• Follows a **PRISMA-compliant** systematic search methodology across multiple databases.

Limitations

• The underlying data is a narrative synthesis, not a structured dataset with rows and columns for computational analysis.
• Findings for **S100A4** and **S100A10** are described as fragmentary and indirect, indicating limited evidence.
• The 22.6 KB file size indicates the document is a summary review, not a primary data collection.

Provenance

Source

Systematic search of PubMed, Embase, Scopus, and Web of Science.

Collection Method

PRISMA-compliant systematic review with independent risk-of-bias assessment.

Time Range

Literature search covered studies up to November 18, 2025.

Freshness

Last updated March 2026, based on a literature search up to November 2025.

Geography

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