Salivary Exosomal TB DNA Diagnostic Performance Data

A 2026 clinical study by Jun Ma evaluating a non-sputum tuberculosis diagnostic method. The dataset includes results from 130 patients with suspected pulmonary tuberculosis, assessing the sensitivity and specificity of a dual-gene qPCR assay on salivary exosomal DNA. It is hosted on figshare under a CC-BY-4.0 license.

Use Cases

• Benchmarking diagnostic assay performance based on reported sensitivity and specificity metrics against microbiological reference standards.
• Analyzing diagnostic outcomes in smear-negative tuberculosis subgroups based on the described patient cohort.
• Evaluating the correlation between salivary exosomal DNA detection and clinical tuberculosis status as described in the study results.

Strengths

• Includes specific performance metrics: sensitivity of 81.2% and specificity of 82.8% against a microbiological reference standard.
• Focuses on a clinically relevant subgroup: 105 out of 130 patients had negative smear microscopy results.
• Describes a concrete technical improvement: the assay reduced turnaround time from 16 hours to 3 hours.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (1.1 MB), which may constrain the scope of analysis.

Provenance

Source

Jun Ma via figshare

Collection Method

Clinical study integrating enrichment of salivary exosomes, nucleic acid extraction, and dual-target qPCR melting curve analysis.

Freshness

Last updated 2026-06-01 04:19:08; freshness should be verified.