Sanyin Decoction Psoriasis Study: Mouse Model Gut Microbiota and Transcriptomic Data

5.2 MB of experimental data from a study on Sanyin decoction's effects on psoriasis-like mice. Huangchao Jia published the dataset on figshare in April 2026. The data likely contains measurements from skin pathology, gut microbiota 16S rRNA sequencing, short-chain fatty acid analysis, and spleen/skin transcriptomic sequencing.

Use Cases

• Correlate changes in gut microbiota abundance (e.g., Lachnospiraceae, Rikenella) with skin pathology scores based on the described experimental results.
• Analyze transcriptomic data to identify differentially expressed genes in spleen and skin lesions related to IL-4 and IL-17 signaling pathways.
• Model the relationship between fecal short-chain fatty acid levels (e.g., acetate) and systemic immune markers like plasma IL-4.
• Investigate the association between regulatory T cell abundance in the spleen and activation of keratinocyte differentiation pathways in the skin.

Strengths

• Data is associated with a multi-modal study design integrating histopathology, microbiome sequencing, and transcriptomics.
• Dataset is licensed under CC-BY-4.0, permitting broad reuse with attribution.
• File size is 5.2 MB, indicating a manageable download and exploration time.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific analytical tasks.
• Data is derived from a controlled mouse model, which may limit direct applicability to human psoriasis studies.

Provenance

Source

figshare

Collection Method

Data generated from a laboratory study using imiquimod-induced psoriasis-like mouse models, with samples analyzed via 16S rRNA sequencing, SCFA analysis, and transcriptomic sequencing.

Time Range

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Freshness

Last updated 2026-04-16 19:01:10; freshness should be verified.

Geography

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