Serum Metabolite Biomarkers for Stroke Outcome Prediction

80 patients with aneurysmal subarachnoid hemorrhage had serum concentrations of short-chain fatty acids and tryptophan-derived metabolites measured on Day 1 and Day 9 post-hemorrhage. Blanka Nagybanyai-Nagy authored this prospective observational study, with data last updated in April 2026. The study links specific metabolite levels to 3-month functional outcome and delayed cerebral ischemia.

Use Cases

• Predict 3-month functional outcome (modified Rankin Scale) using Day 1 propionic acid and Day 9 indole-3-propionic acid levels.
• Identify patients at risk for delayed cerebral ischemia using Day 9 tryptophan, indole-3-propionic acid, and propionic acid concentrations.
• Analyze temporal dynamics of gut-derived metabolites by comparing short-chain fatty acid and indole compound levels between Day 1 and Day 9.
• Build multivariable logistic regression models for outcome prediction using metabolite levels adjusted for established clinical confounders.
• Assess discriminative performance of biomarkers like tryptophan and propionic acid using ROC analysis with reported AUCs.

Strengths

• Data from 80 consecutive patients enrolled at a tertiary neurocritical care center.
• Metabolite concentrations quantified at two specific time points (Day 1 and Day 9) using LC–MS.
• Clinical outcomes assessed at 3 months using the modified Rankin Scale and consensus criteria for DCI.

Limitations

• Small sample size of 80 patients limits statistical power for subgroup analyses.
• Single-center study design may limit generalizability of findings to other populations.
• Dataset scope is limited to a 14.6 KB document containing summary results, not raw measurement data.

Provenance

Source

Prospective observational study by Blanka Nagybanyai-Nagy, published on figshare.

Collection Method

Serum metabolite quantification via LC–MS, clinical assessment using modified Rankin Scale and DCI criteria.

Time Range

Measurements taken on Day 1 and Day 9 after aneurysmal subarachnoid hemorrhage.

Freshness

Last updated in April 2026.

Geography

Patients enrolled at a single tertiary neurocritical care center; specific location unknown.