Serum Neurofilament Light Chain Meta-Analysis for Multiple Sclerosis Prognosis

13 studies with 12,513 patients were meta-analyzed to assess serum neurofilament light chain as a biomarker for multiple sclerosis outcomes. Elevated sNfL was significantly associated with increased risk of clinical relapse and new gadolinium-enhancing lesions. This meta-analysis was authored by Yejun Chen and uploaded to figshare in April 2026.

Use Cases

• Validate prognostic models for multiple sclerosis based on serum neurofilament light chain levels.
• Assess risk of clinical relapse or radiological activity in patients based on baseline biomarker data.
• Inform clinical trial design and patient stratification strategies using pooled meta-analysis results.

Strengths

• Pooled data from 13 studies encompassing 12,513 patients.
• Results show significant associations with multiple clinical and radiological outcomes, such as a risk ratio of 1.42 for new clinical relapse.
• Low heterogeneity (I²≤34.9%) was reported for primary outcomes.

Limitations

• The dataset is a 19.2 KB document; its scope is limited to the meta-analysis summary.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed, Embase, Ovid, and Cochrane databases.

Time Range

Studies searched from January 2015 to January 2026.

Freshness

Last updated 2026-04-28 05:28:04; freshness should be verified.