Serum Steroid Hormone Profiles in Reproductive-Age Women with Systemic Lupus Erythematosus

A cross-sectional study of 39 newly diagnosed, treatment-naïve female SLE patients and 37 matched healthy controls. Serum levels of steroid hormones were quantified using LC-MS/MS and correlated with clinical parameters and disease activity (SLEDAI-2000). The dataset was authored by Xiaotong Chen and last updated on April 22, 2026.

Use Cases

• Identify hormonal biomarkers for SLE disease activity based on correlations with SLEDAI scores and proteinuria.
• Analyze patterns of HPA axis suppression in SLE based on described deficiencies in adrenal and gonadal steroids.
• Investigate associations between specific hormone levels and inflammatory markers like complement C3/C4 and IL-6.
• Compare steroid hormone profiles across menstrual phases in SLE patients based on described progesterone, 17-hydroxyprogesterone, and estradiol levels.

Strengths

• Data includes 39 SLE patients and 37 matched healthy controls, providing a case-control study design.
• Hormone levels were quantified using a specific, high-precision method: liquid chromatography-tandem mass spectrometry (LC-MS/MS).
• Clinical assessment includes a standardized disease activity index (SLEDAI-2000) and inflammatory markers.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 15.6 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Cross-sectional study with fasting blood samples collected from enrolled participants.

Freshness

Last updated 2026-04-22 05:49:33; freshness should be verified.