Human Prenatal T Cell Development Atlas from 7 to 23 Weeks

A single-cell transcriptome atlas integrates five published datasets to characterize CD4+ and CD8+ T cell lineage commitment in the human prenatal thymus. The data covers development from 7 to 23 post-conception weeks and was authored by Yang Yang. The dataset was last updated on May 19, 2026.

Use Cases

• Model asymmetric lineage commitment dynamics based on pseudotime analysis results
• Analyze cell-cell communication networks between thymocytes and stromal cells
• Identify gene expression patterns related to activation, viral response, differentiation, and apoptosis
• Compare signaling and metabolic activities between transitional CD4 and CD8 cell populations

Strengths

• Integrates five published datasets, likely increasing sample diversity
• Focuses on a specific developmental window from 7 to 23 post-conception weeks
• Includes results from pseudotime analysis, regulon profiling, and cell-cell communication modeling

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The 12.8 KB file size suggests a limited scope, likely containing summary results rather than raw expression data

Provenance

Source

figshare

Collection Method

Integrative analysis combining five published single-cell datasets

Time Range

7 to 23 post-conception weeks

Freshness

Last updated 2026-05-19 05:41:50