Single-Cell Transcriptomic Profiles of Halo Nevi and Normal Nevi

Single-cell RNA sequencing data from halo nevi and normal nevi reveals activated CD8+ T cell infiltration and melanocyte-intrinsic interferon responses. The dataset, authored by Wenxuan Gao and last updated in May 2026, provides a transcriptional atlas of ten canonical skin cell types and five melanocyte subclusters. It highlights pathogenic pathways shared with vitiligo that may inform targeted therapies.

Use Cases

• Identify activated, interferon-responsive CD8+ T cell signatures in halo nevi based on scRNA-seq data.
• Compare melanocyte subcluster gene expression, including antigen-presenting molecules and chemokines.
• Analyze upregulated pathways in halo nevi melanocytes, such as oxidative phosphorylation and antigen processing.
• Investigate shared pathogenic mechanisms between halo nevi and vitiligo for therapeutic target discovery.

Strengths

• Data is derived from single-cell RNA sequencing, providing high-resolution transcriptional profiles.
• Includes comparative analysis of two distinct biological states: halo nevi and normal nevi.
• Integrated with immunofluorescence staining for validation, as mentioned in the description.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (24.4 KB), suggesting limited scope or a summary table rather than raw sequencing data.

Provenance

Source

figshare

Collection Method

Single-cell RNA sequencing (scRNA-seq) and immunofluorescence staining.

Time Range

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Freshness

Last updated 2026-05-14 08:46:13; freshness should be verified.

Geography

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