Table 2_Single-cell transcriptomic profiling reveals innate-like cytotoxic intraepithelial

A study of 50 specific-pathogen free chicks challenged with Salmonella Enteritidis, analyzing immune cell responses at 2 and 6 days post-infection. The dataset, authored by Shuja Majeed and last updated in June 2026, likely contains single-cell RNA sequencing and flow cytometry results from ileum samples. It focuses on the expansion of innate-like cytotoxic intraepithelial lymphocytes as a defense mechanism.

Use Cases

• Characterizing transcriptional signatures of innate-like cytotoxic T cells based on scRNA-seq cluster analysis mentioned in the description
• Modeling T cell differentiation trajectories from progenitor to effector states based on inferred trajectory analysis
• Correlating flow cytometry proportions of TCRγδ+CD8αβ+ cells with scRNA-seq transcriptional profiles based on integrated data
• Investigating the role of stem-like resident memory T cells as a reservoir during infection based on the described findings

Strengths

• Includes data from 50 specific-pathogen free chicks across control and infected groups
• Integrates spectral flow cytometry and single-cell RNA sequencing data from two post-infection time points (2 dpi and 6 dpi)
• Released under a permissive CC-BY-4.0 license

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is small (48.7 KB), indicating limited scope or summary-level data

Provenance

Source

figshare

Collection Method

Single-cell RNA sequencing and spectral flow cytometry performed on ileum samples from Salmonella-challenged and control chickens.

Time Range

Samples collected at 2 and 6 days post-infection.

Freshness

Last updated 2026-06-03 04:49:19; freshness should be verified