Mouse Dentate Gyrus Gene Expression After Entorhinal Denervation, 1-28 Days

Tabular data from a whole-genome expression analysis of the mouse dentate gyrus following perforant path transection. The dataset likely contains gene expression changes measured in the outer molecular layer and granule cell layer at 1, 3, 7, 14, and 28 days post-lesion. It was authored by Jessica Schlaudraff and shared under a CC-BY-4.0 license.

Use Cases

• Modeling temporal dynamics of neuroinflammation based on glial and inflammatory factor upregulation.
• Analyzing compensatory synaptic remodeling based on changes in postsynaptic and dendritic membrane regulators.
• Studying layer-specific transcriptional responses based on comparisons between the outer molecular layer and granule cell layer.
• Identifying novel molecular mediators of injury-induced plasticity based on coordinated transcriptomic programs.

Strengths

• Data includes specific temporal measurements at five time points (1, 3, 7, 14, 28 days).
• Analysis is layer-specific, comparing the outer molecular layer and granule cell layer.
• The description provides concrete examples of gene expression changes, such as a 3-fold induction of Nrp1 in the OML.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is small (2.5 MB), which may limit the scope of analysis.

Provenance

Source

figshare

Collection Method

Laser microdissection of mouse brain tissue followed by whole-genome expression analysis.

Time Range

Measurements taken at 1, 3, 7, 14, and 28 days post-lesion.

Freshness

Last updated 2026-05-19 05:40:46; freshness should be verified.