Mouse Proteomic Response to Echinostoma caproni Infection

Proteomic analysis of ileal epithelial cells from ICR mice infected with the intestinal helminth Echinostoma caproni. The dataset, created by Emma Fiallos and last updated in April 2026, likely contains quantified protein expression changes linked to metabolic and immune pathways. Findings reveal upregulation of mitochondrial oxidative phosphorylation proteins and downregulation of fatty acid metabolism proteins.

Use Cases

• Identify biomarkers of host susceptibility based on differential protein expression profiles described in the results.
• Model metabolic pathway disruptions during helminth infection based on the reported upregulation of oxidative phosphorylation and purine metabolism proteins.
• Investigate epithelial barrier dysfunction based on the described downregulation of proteins linked to tight junction maintenance.
• Analyze the skewed immune response profile based on the reported overexpression of antimicrobial peptides and reduction of eosinophil/neutrophil effectors.

Strengths

• Proteomic data generated using LC-MS/MS analysis with DDA and SWATH methods, as described in the methods.
• Analysis focuses on a specific, well-defined model organism (male ICR mice) and parasite (E. caproni) at a defined time point (4 weeks post-infection).
• Dataset is openly shared under a CC-BY-4.0 license, facilitating reuse.

Limitations

• Dataset is very small at 26.3 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.

Provenance

Source

figshare

Collection Method

Proteins were extracted from isolated ileal epithelial cells of infected mice for LC-MS/MS analysis, with differential expression quantified using bioinformatics tools.

Freshness

Last updated 2026-04-21 04:23:07; freshness should be verified.