SBC8803: Zebrafish Gut-Brain Multi-Omics Data for Anxiolytic Probiotic Study

A multi-omics dataset from a zebrafish study investigating the anxiolytic effects of the paraprobiotic Lactobacillus brevis SBC8803. It includes behavioral, brain transcriptomic, and gut microbiome data from adult male AB-strain zebrafish fed the treatment for 4 weeks. The dataset was authored by Azusa Kubota and published on figshare under a CC-BY-4.0 license in May 2026.

Use Cases

• Correlating behavioral anxiety metrics with brain transcriptomic pathways based on the novel tank test and RNA sequencing results described.
• Investigating links between gut microbiome functional shifts and neural signaling based on the integrated 16S rRNA and GSVA/DIABLO analyses mentioned.
• Studying the vitamin B–serotonin–anti-inflammatory axis proposed in the description by analyzing coordinated microbial metabolic and brain signaling data.
• Examining innate gut-brain coordination independent of probiotic treatment based on the residual correlation analysis of arachidonic acid and histidine metabolism.

Strengths

• Integrates three data modalities: behavioral assays, brain RNA sequencing, and 16S rRNA microbiome sequencing from a controlled 4-week feeding study.
• Dataset is openly available under a permissive CC-BY-4.0 license, facilitating reuse and sharing.
• Analysis includes advanced multi-omics integration techniques like GSVA and DIABLO-based data integration, as described.

Limitations

• Row count and specific column definitions are unknown, which limits pre-download assessment of data structure and scale.
• The dataset is very small at 27.9 KB, suggesting it may contain summary or processed results rather than raw sequencing reads.
• Data is from a specific zebrafish model (adult male AB-strain) and a single probiotic treatment, which may limit generalizability.

Provenance

Source

figshare, authored by Azusa Kubota.

Collection Method

Data generated from a laboratory experiment involving dietary intervention, behavioral testing (novel tank test), brain RNA-seq, and 16S rRNA sequencing of intestinal contents.

Freshness

Last updated 2026-05-21 05:35:22.