Table 2_Targeted next-generation sequencing analysis of pathogens and microecology in pedi

A retrospective, single-center study of 2299 children with suspected lower respiratory tract infections, with data from 1845 community-acquired pneumonia patients analyzed. The dataset includes targeted next-generation sequencing results from throat swabs, clinical data, and microbial diversity indices. It was authored by Hongquan Pi and last updated on 2026-04 16.

Use Cases

• Identify risk factors for severe community-acquired pneumonia based on pathogen positivity and clinical variables.
• Analyze correlations between upper respiratory microbial diversity and pneumonia severity.
• Model the association between specific commensal bacteria abundances and disease outcomes.
• Compare pathogen detection profiles between severe and non-severe pneumonia cases.

Strengths

• Includes data from 2299 pediatric patients, with detailed analysis on 1845 CAP cases.
• Contains targeted sequencing results, clinical data, and calculated microbial diversity indices.
• Multivariate analysis identifies specific independent risk factors like Mycoplasma pneumoniae positivity.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the primary table is unknown, which may limit suitability assessment.
• Data is from a single-center retrospective study, which may limit generalizability.

Provenance

Source

figshare

Collection Method

Retrospective analysis of throat swab samples analyzed via targeted next-generation sequencing.

Time Range

Study period includes an outbreak peak in July 2024.

Freshness

Last updated 2026-04-16 05:14:23; freshness should be verified.

Geography

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