TCR Repertoire Shaping in Human Naïve T Cell Subsets

Figshare hosts a dataset analyzing T cell receptor (TCR) β repertoire diversity and structure in sorted naïve T cell subsets. The data covers samples from umbilical cord blood at early gestation (24–29 weeks), term (38–39 weeks), and late-born neonates (40–42 weeks), as well as from children, adults, and older individuals.

Use Cases

• Analyze age-dependent shifts in TCRβ repertoire structure and TRBV gene usage across samples from neonates to older individuals.
• Compare repertoire convergence and public clonotype abundance between umbilical cord blood and adult peripheral blood samples.
• Investigate distinct TCRβ repertoire features in naïve regulatory T cells (Treg) compared to naïve CD4+ and CD8+ subsets.
• Examine changes in predicted CDR2 binding strength across age groups, particularly in naïve Treg and naïve CD8+ T cell repertoires.

Strengths

• Data covers a developmental time range from 24-week gestation to older individuals.
• Includes analysis of three distinct naïve T cell subsets: CD4+, CD8+, and regulatory T cells.
• File size is 33.9 KB, indicating a focused and manageable dataset for targeted analysis.

Limitations

• Dataset is small at 33.9 KB, limiting the scope of large-scale machine learning applications.
• Specific row count, column names, and sample data are unavailable, hindering precise assessment of structure.

Provenance

Source

Mikhail Yu. Myshkin via figshare.

Collection Method

TCRβ repertoire analysis performed on sorted naïve T cell subsets from blood samples.

Time Range

Covers samples from early gestation (24–29 weeks) to older individuals.

Freshness

Last updated March 25, 2026.

Geography

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