Temporal Transcriptional Dynamics in a Mouse Model of Cutaneous Leishmaniasis
by Jessica Lobo-Silva·Updated 1mo ago
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Description
A longitudinal transcriptomic analysis of skin lesions and draining lymph nodes in a BALB/c mouse model infected with Leishmania braziliensis, spanning from 2 hours to 77 days post-infection. The dataset, created by Jessica Lobo-Silva and last updated in May 2026, includes bulk RNA sequencing results characterizing differential gene expression, pathway enrichment, and gene co-expression networks. It recapitulates 77% of inflammatory pathways found in human cutaneous leishmaniasis and identifies conserved non-coding RNAs and epigenetic regulators.
Use Cases
Identify host-directed therapeutic targets based on conserved microRNAs and epigenetic regulators like Mir155 and Kdm6b.
Analyze stage-specific immune responses based on gene co-expression modules associated with early innate responses, tissue damage, and skin barrier remodeling.
Perform cross-species comparison of ulcerated lesions based on the conserved pathways and regulators identified.
Study the dynamics of macrophage polarization and nitric oxide metabolism based on upregulated genes such as Il12a, Il12b, Arg1, and Nos2.
Strengths
Longitudinal design with data points from 2 hours to 77 days post-infection.
Cross-species validation showing mouse lesions recapitulate 77% of inflammatory pathways from human cutaneous leishmaniasis.
Identifies 16 conserved microRNAs and 12 shared epigenetic regulators as potential therapeutic targets.
Limitations
Column-level documentation is absent; field semantics must be inferred after download.
Row count is unknown, which may limit suitability assessment.
Data is from a specific mouse model (BALB/c ear dermal model), which may limit generalizability.
Provenance
Source
figshare
Collection Method
Bulk RNA sequencing performed on skin lesions and draining lymph nodes from infected mice.
Time Range
Data collected from 2 hours to 77 days post-infection.
Freshness
Last updated 2026-05-12 04:20:18; freshness should be verified.