Bile Acid and Gut Microbiota Alterations in Aging, 200 Participants

100 elderly and 100 young participants were enrolled in this study to investigate links between aging, bile acids, and gut microbiota. Fecal and serum bile acids were quantified by LC-MS/MS, and gut microbiota composition was assessed via 16S rRNA gene sequencing. The dataset, authored by Yumei Xu and last updated in April 2026, shows correlations between these biomarkers and markers of intestinal barrier dysfunction and chronic inflammation.

Use Cases

• Correlating bile acid profiles with age based on LC-MS/MS measurements of fecal and serum samples.
• Analyzing shifts in gut microbiota composition associated with aging using 16S rRNA sequencing data.
• Investigating relationships between specific bile acids like lithocholic acid and inflammatory markers IL-6 and TNF-α.
• Modeling the association between the primary/secondary bile acid ratio and markers of intestinal barrier dysfunction.

Strengths

• Includes data from 200 participants (100 elderly, 100 young), providing a comparative cohort.
• Multiple biomarker types measured: bile acids via LC-MS/MS, microbiota via 16S rRNA, and cytokines via ELISA.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The cross-sectional study design, noted in the description, prevents establishing causal relationships.

Provenance

Source

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Collection Method

Data collected from participant fecal and serum samples analyzed with LC-MS/MS, 16S rRNA sequencing, and ELISA.

Time Range

Study period not specified in input.

Freshness

Last updated 2026-04-15 05:42:22; freshness should be verified.

Geography

Participant geography not specified in input.