In Vivo Efficacy Data for EM86-Loaded Nanofibrous Wound Dressings

Experimental results detail the in vivo performance of an electrospun nanofibrous dressing functionalized with the antimicrobial peptide EM86 against multidrug-resistant Pseudomonas aeruginosa wound infections in BALB/c mice. The data includes peptide loading amounts, bacterial count reductions, and scaffold characterization metrics like fiber diameter and swelling capacity. Samar Essam Metwally authored this study, which was last updated in April 2026.

Use Cases

• Analyze bacterial count reduction (P. aeruginosa SM016) after treatment with EM86-loaded dressings compared to untreated controls.
• Correlate EM86 loading amount (35 ± 18 μg) with in vivo antibacterial efficacy metrics.
• Evaluate scaffold properties like mean fiber diameter (238 ± 78 nm) and swelling capacity (510%) in relation to treatment outcomes.
• Assess the safety profile of EM86 using its IC50 value (>300 μg/mL) against human skin fibroblasts.

Strengths

• Includes specific, quantified results such as a 510% swelling capacity for the dressing scaffold.
• Reports statistically significant reductions in bacterial counts (P < 0.001) from in vivo mouse model testing.

Limitations

• Dataset is very small at 29.3 KB, indicating limited scope, likely summarizing key results rather than raw experimental data.
• No raw columnar data or sample rows are provided, only summarized findings from the research article.

Provenance

Source

Research article by Samar Essam Metwally, published on figshare.

Collection Method

Generated from in vitro and in vivo laboratory experiments, including electrospinning, gamma-irradiation, and mouse model infection studies.

Freshness

Last updated April 2026.