TyG Index Meta-Analysis: Association with Pregnancy Complications and Outcomes

Wenli Zhang's systematic review and meta-analysis, uploaded on 2026-04-23, investigates the relationship between the Triglyceride-Glucose index in early pregnancy and adverse outcomes. The analysis includes 23 studies with a total of 220,985 participants, of which 61,774 had a high TyG index. It concludes that a high TyG index is positively associated with risks like gestational diabetes, preeclampsia, and preterm birth.

Use Cases

• Assessing the TyG index as a predictive biomarker for gestational diabetes based on the meta-analysis results.
• Evaluating the association between early pregnancy insulin resistance and hypertensive disorders like preeclampsia.
• Investigating links between maternal metabolic markers and neonatal outcomes such as macrosomia and large for gestational age.

Strengths

• Includes data from 23 studies with a total of 220,985 participants.
• Systematic review protocol is registered with PROSPERO (CRD420261293271).
• Analysis covers multiple pregnancy complications and adverse outcomes.

Limitations

• The dataset is a 29.5 KB DOCX file, which is a small document rather than a primary data table.
• Row count and column-level documentation for the underlying meta-analysis data are unknown.
• Data freshness should be verified as the search period extends to a future date (December 28, 2025).

Provenance

Source

Wenli Zhang, via figshare.

Collection Method

Systematic review and meta-analysis of studies from databases including CNKI, PubMed, Embase, and Web of Science.

Time Range

Studies from database inception to December 28, 2025.

Freshness

Last updated 2026-04-23 05:35:11.