Meta-Analysis of Dietary Nitrate Effects on Weight and Lipid Parameters from 8 RCTs

A systematic review and meta-analysis of eight randomized controlled trials involving 199 participants, evaluating the effects of dietary nitrate supplementation on obesity-related outcomes. The analysis, conducted by Wenjun Cai and adhering to PRISMA 2020 guidelines, found significant reductions in systolic blood pressure, total cholesterol, and triglycerides, but no significant effect on body weight or BMI. The dataset was last updated in April 2026.

Use Cases

• Conducting a secondary meta-analysis based on the reported effect sizes and confidence intervals for systolic blood pressure
• Investigating the relationship between intervention duration and blood pressure outcomes based on the described subgroup analysis
• Assessing publication bias in obesity research based on the mention of detected bias for BMI and diastolic blood pressure
• Analyzing the heterogeneity of treatment effects across studies based on the reported I² statistics for various outcomes

Strengths

• Includes data from 8 randomized controlled trials, a standard for clinical evidence
• Reports specific statistical metrics including standardized mean differences (SMDs), confidence intervals, p-values, and I² statistics for heterogeneity
• Adheres to PRISMA 2020 reporting guidelines for systematic reviews

Limitations

• The total sample size of 199 participants is relatively small for a meta-analysis
• Column-level documentation is absent; field semantics must be inferred after download
• Publication bias was detected for some outcomes (BMI and diastolic blood pressure), which may affect the validity of those results

Provenance

Source

figshare, author Wenjun Cai

Collection Method

Systematic review and meta-analysis of RCTs from PubMed, Scopus, Web of Science, and Embase

Time Range

Literature search conducted up to April 2026

Freshness

Last updated 2026-04-28 05:24:30; freshness should be verified