Human-Specific Genetic Variants Linked to Neuronal Spinogenesis

4.3% of curated human-specific genes and genetic variants are linked to dendritic spines, according to this analysis. The dataset was created by Nicolás Matías Rosas and published on figshare under a CC-BY-4.0 license, with a last update in June 2026. It likely contains tabular data summarizing the effect of these variants on pathways like cytoskeleton, Ca2+ signaling, small GTPases, NMDAR, and WNT signaling.

Use Cases

• Identifying candidate genes for human-specific brain features based on curated genetic variant lists.
• Analyzing the convergence of genetic variants on canonical pathways like cytoskeleton and Ca2+ signaling.
• Prioritizing research targets for neuropsychiatric disorder treatments based on human-specific genetic contributions.
• Supporting environmental neuroscience studies for early childhood intervention and dementia risk reduction.

Strengths

• Focuses on a curated list of human-specific genes and genetic variants.
• Identifies a specific 4.3% subset linked to dendritic spines.
• Published under a permissive CC-BY-4.0 license.
• Last updated date (2026-06-03) is provided.

Limitations

• The dataset is very small at 26.7 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Systematic query of a curated list of human-specific genes and genetic variants.

Freshness

Last updated 2026-06-03 02:36:52; freshness should be verified.