Table 2_The efficacy and safety of colistimethate sodium in the treatment of carbapenem-re

A prospective observational study in nine ICUs across Henan Province, China, from November 2021 to November 2023. The dataset includes 222 patients aged 14 and over with culture-confirmed carbapenem-resistant Gram-negative bacilli infections treated with colistimethate sodium. It was authored by Tingyuan Zhang and evaluates clinical response, 30-day mortality, and adverse events like acute kidney injury.

Use Cases

• Modeling risk factors for poor clinical response based on APACHE II scores, infection site, and microbial profile.
• Analyzing the incidence and severity of acute kidney injury associated with colistimethate sodium treatment.
• Comparing clinical and microbiological response rates across patient subgroups, such as those with single-site versus multi-site infections.
• Investigating the relationship between baseline serum creatinine levels and the risk of developing acute kidney injury.

Strengths

• Data is from a prospective, observational study design, which likely provides structured clinical data.
• Includes results for 222 consecutively enrolled patients, providing a defined cohort size.
• Reports specific outcome metrics, including an 82.5% clinical response rate and a 30-day all-cause mortality of 19.8%.
• Contains subgroup analysis results for factors like infection site and microbial profile.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying data table is unknown, which may limit suitability assessment.
• Data reflects a specific geographic and temporal context (Henan Province ICUs, 2021-2023), which may limit generalizability.

Provenance

Source

Tingyuan Zhang, via figshare.

Collection Method

Prospective observational study with consecutive enrollment of patients from nine ICUs.

Time Range

November 2021 to November 2023

Freshness

Last updated 2026-05-29 04:45:28; freshness should be verified.

Geography

Henan Province, China