Meta-Analysis Results on Vitamin D and Childhood Asthma from 12 RCTs

A systematic review and meta-analysis of 12 randomized controlled trials involving 1239 children with asthma. The study, authored by Runze Li and published on figshare in 2026, evaluates the efficacy of vitamin D supplementation on lung function and other clinical outcomes. It reports standardized mean differences and confidence intervals for primary and secondary outcome measures.

Use Cases

• Assess the effect of vitamin D supplementation on FEV1 (%) based on the primary outcome measure.
• Analyze the impact on secondary outcomes like FVC (%), FEV1/FVC, and PEF based on the reported measures.
• Evaluate changes in clinical asthma control test (cACT) scores based on the reported mean difference.
• Investigate the relationship between supplementation and biomarkers like FeNO and IgE levels based on the reported results.

Strengths

• The analysis is based on 12 randomized controlled trials, a standard for clinical evidence.
• It reports results for 7 distinct clinical outcome measures, including FEV1 (%), FVC (%), FEV1/FVC, PEF, FeNO, cACT, and IgE.
• The dataset includes specific statistical results such as standardized mean differences and 95% confidence intervals.

Limitations

• The dataset is a 16.8 KB document file; the underlying raw trial data is not provided.
• Row count and column-level documentation are unknown, limiting direct analysis of individual patient data.
• Data freshness should be verified as the literature search concluded on October 31, 2025.

Provenance

Source

Runze Li via figshare

Collection Method

Systematic review and meta-analysis of RCTs from PubMed, EMBASE, Web of Science, and Cochrane Library.

Time Range

Literature search up to October 31, 2025.

Freshness

Last updated 2026-05-19 05:45:49