Pediatric Fever of Unknown Origin Etiology and Management in China 2014-2024

A ten-year retrospective study from Fudan University Children's Hospital analyzes 442 pediatric Fever of Unknown Origin (FUO) cases. The data details etiological distributions, clinical features like age at onset and episode intervals, and treatment responses for conditions including PFAPA and SURF.

Use Cases

• Analyze the distribution of etiologies, such as infectious diseases (20.6%) versus autoinflammatory diseases (n=291), across the 442 pediatric FUO cases.
• Model the relationship between clinical characteristics like mean age at onset (3.42 years) and subtype classification, such as PFAPA (mean age 2.25 years) versus SURF periodic/non-periodic.
• Evaluate treatment efficacy metrics, including corticosteroid abortive rates (90.9% for PFAPA) and complete remission rates from tonsillectomy (90.5%) or immunomodulation like OM-85 (45.0%).
• Compare laboratory parameters during attacks, such as elevated CRP/ESR with neutrophilia/monocytosis and lymphopenia, between PFAPA and SURF patient groups.

Strengths

• Clinical data from 442 pediatric patients provides a substantive cohort for analysis.
• Ten-year temporal coverage from 2014 to 2024 offers longitudinal insight.
• Includes detailed clinical metrics like treatment response rates and laboratory parameters.

Limitations

• The dataset is very small at 9.7 KB, indicating limited scope and likely summary-level data rather than individual patient records.
• Data is from a single hospital in China, limiting geographic generalizability.
• Specific column names and row counts for analytical variables are unknown.

Provenance

Source

Chenchen Guan, Fudan University Children's Hospital.

Collection Method

Retrospective analysis of pediatric FUO cases.

Time Range

2014 to June 2024.

Freshness

Data covers up to June 2024 and was last updated in March 2026.

Geography

China (Fudan University Children's Hospital).