Genetic Architecture of Parkinson's Disease in Mexico: A Systematic Review

A systematic review synthesizing genetic studies of Parkinson's disease conducted in Mexico, covering 24 studies with 7,048 participants published between 2004 and 2025. The review, authored by Oscar Arias-Carrión and published on figshare, harmonizes findings on 27 genes and 71 distinct genetic variants. It provides a quality-assessed synthesis highlighting recurrently associated loci and population-specific genetic risk architecture.

Use Cases

• Identify population-specific genetic risk factors for Parkinson's disease based on the 8 recurrently associated loci reported.
• Benchmark genetic study methodologies and quality for Mexican cohorts based on the PRISMA 2020 guidelines and Q-Genie instrument appraisal mentioned.
• Investigate functional pathways like mitochondrial quality control and lysosomal-autophagic processes based on the integrated Gene Ontology and WikiPathways analyses.
• Design ancestry-aware genomic studies for Parkinson's disease based on the review's conclusions regarding limited ancestry-aware analyses in existing literature.

Strengths

• Synthesizes data from 24 original studies involving 7,048 total participants (3,367 patients and 3,781 controls).
• Covers a substantial time range, reviewing literature published between 2004 and February 2025.
• Employs a systematic methodology following PRISMA 2020 guidelines and uses the Q-Genie instrument for quality appraisal.
• Harmonizes variant nomenclature using HGNC and dbSNP identifiers for standardized analysis.

Limitations

• The dataset is a 33.2 KB DOCX document, indicating a limited scope focused on review text rather than primary genetic data.
• Column-level documentation and sample data are unavailable, requiring manual inspection of the document's structure after download.
• The review notes substantial methodological heterogeneity and limited ancestry-aware analyses in the underlying studies it synthesizes.

Provenance

Source

figshare

Collection Method

Systematic literature review following PRISMA 2020 guidelines.

Time Range

Studies published between 2004 and February 2025.

Freshness

Last updated 2026-03 17 13:08:42.

Geography

Mexico