Kailuan Study: Inflammation and Lung Cancer Risk by Subtype

99,925 participants from the Kailuan cohort were followed for a mean of 14.85 years to study chronic inflammation's link to lung cancer. The analysis identified 1,804 incident lung cancer cases and evaluated 15 inflammatory indicators, including novel composite indices SIRI and AISI. Associations were found to vary by pathological subtype, with SIRI showing the strongest effects, particularly for squamous cell carcinoma.

Use Cases

• Training risk prediction models based on inflammatory markers like SIRI and AISI.
• Analyzing differential risk associations for lung cancer subtypes such as squamous cell carcinoma.
• Investigating effect modification by demographic factors like age, sex, and smoking status.
• Validating composite inflammatory indices for long-term and 10-year cancer risk assessment.

Strengths

• Large cohort of 99,925 participants with a long mean follow-up of 14.85 years.
• Analysis includes 15 specific inflammatory indicators, including novel composite indices.
• Results are stratified by pathological subtype, age, sex, and smoking status.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying data table is unknown, which may limit suitability assessment.
• The dataset is a 95.5 KB DOCX file, suggesting it contains summary results rather than raw participant-level data.

Provenance

Source

figshare, author Songlin Li.

Collection Method

Cohort study from the Kailuan cohort.

Time Range

Mean follow-up period of 14.85 years.

Freshness

Last updated 2026-04-27 04:11:33; freshness should be verified.

Geography

Likely the Kailuan community in China, though not explicitly stated.