Meta-Analysis of Fluoxetine's Influence on Blood Pressure from RCTs

Deyun Huang published a meta-analysis on figshare in 2026 evaluating the influence of fluoxetine on blood pressure. The analysis includes five randomized controlled trial arms encompassing 538 participants, with pooled estimates calculated using a DerSimonian and Laird random-effects model. Results indicate fluoxetine treatment was associated with statistically significant increases in systolic and diastolic blood pressure, though findings are limited by heterogeneity and a small number of studies.

Use Cases

• Assessing the cardiovascular risk profile of fluoxetine based on the meta-analysis results
• Informing clinical guidelines for blood pressure monitoring during antidepressant treatment based on the reported weighted mean differences
• Designing follow-up clinical studies on drug side effects based on the identified knowledge gaps and heterogeneity

Strengths

• Analysis is based on five randomized controlled trial arms, a gold-standard study design
• Includes specific quantitative results: weighted mean differences of 7.47 mmHg for SBP and 4.19 mmHg for DBP
• Published under a permissive CC-BY-4.0 license allowing for reuse

Limitations

• The dataset is a 52.6 KB DOCX document, not a structured data file; column-level documentation is absent
• Substantial heterogeneity and a limited number of included studies restrict the clinical applicability of the findings
• Row count is unknown, which may limit suitability assessment for quantitative analysis

Provenance

Source

Deyun Huang via figshare

Collection Method

Systematic review and meta-analysis of randomized controlled trials comparing fluoxetine with placebo, sourced from Scopus, Web of Science, Embase, and PubMed/MEDLINE.

Time Range

Literature search covered all records up to July 28, 2025.

Freshness

Last updated 2026-05-28 06:17:17