Gut Microbiota and Septic Cardiomyopathy Biomarkers from Transcriptome and MR Analysis

STAT3 and SLC5A1 were identified as candidate biomarkers linking gut microbiota to septic cardiomyopathy through Mendelian randomization and transcriptome analysis. The 23.5 KB Excel file contains results from a study by Yuxia Tao, last updated in May 2026. Clinical validation showed elevated IL-6 and cTnI levels and decreased propylene glycol in SCM patients.

Use Cases

• Validate causal links between specific gut microbiota and septic cardiomyopathy based on Mendelian randomization results.
• Investigate the role of biomarkers STAT3 and SLC5A1 in pathways like valine, leucine, and isoleucine degradation.
• Analyze immune cell infiltration patterns, such as MDSCs and activated dendritic cells, in septic cardiomyopathy.
• Explore regulatory networks involving transcription factors (e.g., FOXC1) and microRNAs (e.g., miR-3120-3p) for the identified biomarkers.
• Perform molecular docking simulations using metabolite data like propylene glycol against biomarker proteins.

Strengths

• Results are validated with clinical samples measuring IL-6, cTnI, and propylene glycol concentrations.
• Analysis integrates multiple public data sources and methods: GWAS, Mendelian randomization, differential expression, and machine learning.
• Identifies 5 key gut microbiota genera and 22 associated metabolites from public databases.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• The dataset is very small (23.5 KB), indicating it likely contains summary results rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred from the description.

Provenance

Source

figshare, author Yuxia Tao.

Collection Method

Integrated analysis of public GWAS data, Mendelian randomization, differential expression, and machine learning, validated with clinical ELISA, GC-MS, and RT-qPCR.

Freshness

Last updated 2026-05-04 09:32:32; freshness should be verified.