Huntington's Disease and Autoimmune Disease Association Analysis from Enroll-HD

A clinical research dataset analyzing the association between the pathological Huntingtin CAG triplet expansion and autoimmune diseases in Huntington's disease mutation carriers. The data originates from the Enroll-HD periodic dataset #5 from European sites, comprising 10,594 mutation carriers and 2,477 control participants. It was authored by Moritz Heyd and last updated in May 2026.

Use Cases

• Analyze the differential risk of specific autoimmune diseases (e.g., Hashimoto thyroiditis, psoriasis) based on CAG repeat length.
• Investigate the relationship between CAG repeat size and the frequency of organ-specific autoimmune disease subgroups.
• Model the odds of autoimmune disease in Huntington's disease carriers adjusted for factors like sex, age, and functional impairment.

Strengths

• Includes a substantial cohort of 10,594 Huntington's disease mutation carriers and 2,477 control participants.
• Provides specific odds ratios and confidence intervals for disease associations, such as a 0.69 odds ratio for Hashimoto thyroiditis.
• Data is derived from the standardized Enroll-HD clinical research platform.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to its source, being limited to European sites from Enroll-HD.

Provenance

Source

Enroll-HD periodic dataset #5 (European sites)

Collection Method

Analysis of comorbidities coded using abbreviated ICD-10 within the Enroll-HD dataset.

Time Range

The specific time range of data collection is not provided in the description.

Freshness

Last updated 2026-05-08 05:51:30; freshness should be verified.

Geography

Data is from European sites participating in the Enroll-HD study.