Therapeutic Strategies for Idiopathic Granulomatous Mastitis: An Umbrella Review

An umbrella review of six systematic reviews and meta-analyses published between 2017 and 2026 on treatment strategies for idiopathic granulomatous mastitis. The dataset, created by Shuyu Yao and last updated in June 2026, includes assessments of remission, recurrence, and safety outcomes for medical, surgical, and combined therapies. It comprises 97 unique primary studies identified across the reviews.

Use Cases

• Comparing the efficacy of steroid-based combination therapy versus monotherapy based on the review's findings.
• Evaluating the methodological quality of existing systematic reviews on granulomatous mastitis using the AMSTAR-2 assessment mentioned.
• Analyzing study overlap in meta-analyses using the Corrected Covered Area (CCA) metric of 3.30% provided in the results.
• Investigating the relative performance of local steroid therapy and methotrexate-based therapy as described in the review conclusions.

Strengths

• Includes six systematic reviews and meta-analyses, one of which is a network meta-analysis, providing multiple levels of evidence synthesis.
• Assesses 97 unique primary studies, offering a broad view of the existing literature.
• Evaluates methodological quality using the AMSTAR-2 tool, providing transparency on review limitations.
• Quantifies study overlap with a Corrected Covered Area (CCA) of 3.30%, indicating slight redundancy.

Limitations

• The overall methodological quality of the included reviews was suboptimal, with three rated as low and three as critically low.
• The underlying evidence is described as predominantly observational, limiting the certainty of conclusions.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare, author Shuyu Yao.

Collection Method

Systematic search of PubMed, Embase, the Cochrane Library, and Web of Science for systematic reviews or meta-analyses.

Time Range

Reviews published between 2017 and 2026; primary literature search extended to March 2026.

Freshness

Last updated 2026-06-03 06:07:05