Thyroid Autoimmunity and Cardiometabolic Phenotype in Women with Polycystic Ovary Syndrome

A cross-sectional study of 1,300 women with confirmed PCOS, authored by Natalia Piórkowska and last updated in May 2026. It investigates whether thyroid autoimmunity is associated with a more severe cardiometabolic or androgenic phenotype using pre-specified exposure definitions and endpoints.

Use Cases

• Assessing the association between thyroid autoimmunity and triglyceride-to-HDL cholesterol ratio based on the primary endpoint definition
• Evaluating links between anti-TPO positivity and impaired glucose tolerance based on OGTT results mentioned in the description
• Comparing cardiometabolic parameters across different definitions of thyroid autoimmunity (TAI_A, TAI_B, TAI_C) as described
• Conducting sensitivity analyses on metabolic associations by restricting data to euthyroid participants as outlined in the methods

Strengths

• Dataset includes 1,300 women with confirmed PCOS, providing a substantial sample size for analysis
• Analysis uses pre-specified, rigorous statistical methods including age-adjusted Firth logistic regression and false discovery rate correction
• Multiple sensitivity analyses were performed, including restriction to euthyroid participants and trimming of extreme values

Limitations

• The dataset is very small (7.4 KB), suggesting it contains summary results or a manuscript rather than raw patient-level data
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment for machine learning tasks

Provenance

Source

figshare

Collection Method

Cross-sectional analysis of a source dataset of women with PCOS.

Freshness

Last updated 2026-05-01 04:14:20